Egyptian Journal of Obesity, Diabetes and Endocrinology

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 3  |  Issue : 3  |  Page : 95--99

A putative role for oxidative stress in pathophysiology of diabetic cardiomyopathy


Mohamed Fathelbab1, Eman M Fahmy2, Amr A Elshormilisy2, Ahmed E Gaafar3, Nermien E Waly1 
1 Department of Physiology, Faculty of Medicine, Helwan University, Helwan, Egypt
2 Department of Internal Medicine, Faculty of Medicine, Helwan University, Helwan, Egypt
3 Department of Cardiology, Faculty of Medicine, Helwan University, Helwan, Egypt

Correspondence Address:
Ahmed E Gaafar
Department of Cardiology, Faculty of Medicine, Helwan University, Cairo 11795
Egypt

Objectives Cardiovascular disease associated with diabetes remains the leading cause of morbidity and mortality worldwide. There is a growing scientific and public interest in connecting oxidative stress as a cause of endothelial dysfunction associated with pathological conditions such as diabetes mellitus (DM). Free radicals’ scavengers play a pivotal role in maintaining homeostasis. We investigated potential risk factors and the role of oxidative stress in the pathophysiology of diabetic cardiomyopathy. Patients and methods Eighty type 2 DM patients along with 65 normal healthy volunteers were recruited for this study. We calculated BMI, and measured arterial blood pressure. We measured glycosylated hemoglobin (HbA1C), lipid profile levels, catalase, nitric oxide, the enzymes superoxide dismutase, and malondialdehyde in plasma. Results We found that the mean BMI (32.63±3.42), HbA1C (8.07±1.39), malondialdehyde (1007.21±299.341), and nitric oxide (6.79±1.95) were significantly higher in the patient group compared with the control group. On the other hand, superoxide dismutase (2.97±0.69) and catalase (35.44±10.56) in diabetic patients were significantly lower compared with controls. Conclusion Our results confirm the role of oxidative stress in pathophysiology of DM. This suggests that antioxidants may have a putative therapeutic and a prognostic role in diabetic cardiomyopathy.


How to cite this article:
Fathelbab M, Fahmy EM, Elshormilisy AA, Gaafar AE, Waly NE. A putative role for oxidative stress in pathophysiology of diabetic cardiomyopathy.Egypt J Obes Diabetes Endocrinol 2017;3:95-99


How to cite this URL:
Fathelbab M, Fahmy EM, Elshormilisy AA, Gaafar AE, Waly NE. A putative role for oxidative stress in pathophysiology of diabetic cardiomyopathy. Egypt J Obes Diabetes Endocrinol [serial online] 2017 [cited 2018 Jun 22 ];3:95-99
Available from: http://www.ejode.eg.net/article.asp?issn=2356-8062;year=2017;volume=3;issue=3;spage=95;epage=99;aulast=Fathelbab;type=0