Year : 2015 | Volume
: 1 | Issue : 1 | Page : 43--48
Study of vitamin D level in type 2 diabetic patients before and after treatment with pioglitazone
MR Halaw, MM Abu Shady, YM Eid, AA EL Sherbeney, WW Mohamed
Department of Internal Medicine, Ain Shams University, Cairo, Egypt
The aim of this study was to evaluate vitamin D level in type 2 diabetic patients before and after treatment with pioglitazone and assess any possible relationship with type 2 diabetic patients who are pioglitazone naive.
Participants and Methods
The study included 50 female participants; of them, 20 were healthy female participants who served as controls and 30 were pioglitazone-naive diabetic patients. All individuals were subjected to history taking and clinical examination, including fasting blood sugar, 2 h postprandial, glycosylated hemoglobin (HbA1c), lipid profile test (total cholesterol, HDL, LDL, triglycerides), kidney function tests (serum creatinine and calculated glomerular filtration rate), and evaluation of serum calcium, phosphorus, and alkaline phosphatase and serum 25-hydroxy vitamin D (by enzyme linked immunosorbant assay) before (basal) and after 3 months of treatment with pioglitazone.
There was an nonsignificant elevation of vitamin D in group 2b (diabetic patients after using pioglitazone for 3 months), in comparison with vitamin D level in group 2a (diabetic patients before using pioglitazone) (P = 0.117). Vitamin D levels were found to be inversely associated with HbA1c levels in type 2 diabetic patients (P = 0.000 linear regression analysis); it was also found to be inversely associated with fasting and 2 h postprandial blood sugar levels (P < 0.000).
Vitamin D could impact glycemic control in terms of the inverse relation of vitamin D with HbA1c%, and at the same time poor glycemic control could impact vitamin D status in uncontrolled diabetic patients. Thiazolidinediones do not have significant effect on vitamin D level in female diabetic patients.
A A EL Sherbeney
Department of Internal Medicine, Ain Shams University, 1234, Cairo
|How to cite this article:|
Halaw M R, Abu Shady M M, Eid Y M, EL Sherbeney A A, Mohamed W W. Study of vitamin D level in type 2 diabetic patients before and after treatment with pioglitazone.Egypt J Obes Diabetes Endocrinol 2015;1:43-48
|How to cite this URL:|
Halaw M R, Abu Shady M M, Eid Y M, EL Sherbeney A A, Mohamed W W. Study of vitamin D level in type 2 diabetic patients before and after treatment with pioglitazone. Egypt J Obes Diabetes Endocrinol [serial online] 2015 [cited 2020 Sep 23 ];1:43-48
Available from: http://www.ejode.eg.net/article.asp?issn=2356-8062;year=2015;volume=1;issue=1;spage=43;epage=48;aulast=Halaw;type=0