Year : 2015 | Volume
: 1 | Issue : 1 | Page : 36--42
Clinical significance of serum adipokine visfatin/eNampt in relation to prostate cancer detection and aggressiveness
Salwa H Gomaa1, Tamer M Abou Youssif2, Mostafa Elmissery2, Saba Elgendy3
1 Department of Chemical Pathology, Medical Research Institute, Alexandria University, Alexandria, Egypt
2 Department of Urology, Faculty of Medicine, Alexandria University, Alexandria, Egypt
3 Department of Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt
Prostate cancer is a common malignancy ranked as the second most common cause of cancer and the fifth cause of cancer-related mortality worldwide. The association between obesity and prostate cancer remains poorly understood, but evidence suggests that obesity may adversely affect the risk of developing high-grade disease. Adipokines may contribute toward the molecular basis for a link between obesity and prostate cancer. Several studies have shown the role of visfatin in different cancers including astrocytomas, myeloma, and male oral squamous cell; gastric, endometrial, hepatocellular, and colorectal carcinomas; and invasive breast cancer.
In the present study, we attempted to investigate whether a high serum level of visfatin is a good biomarker associated with prostate cancer, especially high-grade cancer, and in obese patients; then, it could be used as a biomarker for the detection of prostate cancer and to determine its aggressiveness.
Participants and method
The present study included 89 individuals divided as follows: 15 age-matched volunteers, control group (group I), 36 patients diagnosed with benign prostatic hyperplasia (BPH group) (group II), and 38 patients diagnosed with prostate cancer (PC group) (group III).
There was a statistically significant increase in serum visfatin level in PC patients (group III) compared with both the controls (group I) and patients with BPH (group II) (P < 0.001, P < 0.001, respectively). In PC patients, the median value of serum visfatin was 55.36 ng/ml (44.32-94.02), whereas it was 12.06 ng/ml (10.36-17.74) in the BPH group and 14.89 ng/ml (10.68-18.62) in the control group. BMI, visfatin, and prostatic-specific antigen were found to be the major significant determinants of the tumor grade (Gleason score) of PC (with a 95% confidence interval 0.096-0.233, P < 0.001; 0.083-0.016, P = 0.005; and 0.001-0.019, P = 0.033, respectively).
In this study, we found a significant positive association between serum visfatin and PC, especially in obese individuals, and we suggest that visfatin could be used as a new promising biomarker for PC; further investigations are warranted to confirm its role in the diagnosis of PC and to assess its aggressiveness.
Salwa H Gomaa
Lecturer of Chemical Pathology, Medical Research Institute, Alexandria University, 165 El-Horreya Avenue, El- Hadra, Alexandria 21561
|How to cite this article:|
Gomaa SH, Abou Youssif TM, Elmissery M, Elgendy S. Clinical significance of serum adipokine visfatin/eNampt in relation to prostate cancer detection and aggressiveness.Egypt J Obes Diabetes Endocrinol 2015;1:36-42
|How to cite this URL:|
Gomaa SH, Abou Youssif TM, Elmissery M, Elgendy S. Clinical significance of serum adipokine visfatin/eNampt in relation to prostate cancer detection and aggressiveness. Egypt J Obes Diabetes Endocrinol [serial online] 2015 [cited 2020 Aug 6 ];1:36-42
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