• Users Online: 422
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
Year : 2017  |  Volume : 3  |  Issue : 2  |  Page : 39-45

The role of genetic polymorphism of β3-adrenergic receptor in the susceptibility to diabetes and its related disorders: a case–control study on Egyptian population

1 Department of Biochemistry, Endocrine and Metabolism Unit, Ain Shams University, Cairo, Egypt
2 Department of Internal Medicine, Endocrine and Metabolism Unit, Ain Shams University, Cairo, Egypt
3 Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
4 Department of Community Medicine, Zagazig University, Zagazig, Egypt

Correspondence Address:
Mona M Abdelsalam
Assistant Professor Endocrinology and Metabolism, Department of Internal Medicine, Endocrinology and Metabolism Unit, Faculty of Medicine, Ain Shams University, Abbassia Square, Cairo 11381
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ejode.ejode_8_17

Rights and Permissions

Background The β3-adrenergic receptor (β3-AR) is mainly expressed in adipose tissue and plays an important role in lipid metabolism and metabolic rate by mediating lipolysis and thermogenesis. It has been suggested that the Trp64Arg (T→C) polymorphism in the β3-AR gene affects fat accumulation and/or impairment of lipid and carbohydrate metabolism. Objective The aim of this study was to investigate whether common polymorphism (Trp64Arg) of β3-AR gene has a role in the apparent susceptibility to type 2 diabetes mellitus (DM) and its related disorders in the Egyptian population. Patients and methods One hundred and thirty five healthy controls and 123 individuals with type 2 DM were enrolled in the study. The β3-AR Trp64Arg polymorphism was identified using restriction fragment length polymorphism PCR of peripheral blood DNA samples. Analysis of data was performed using SPSS program 11. Results Allele frequency for C was 23.2% in the diabetic group compared with 12.2% in the control group. The carriers of XC genotype (TC and CC) were at high risk of developing type 2 DM (odds ratio=2.8; 95% confidence interval=1.6–4.9) when compared with the carrier of TT genotype. Furthermore, they were at much higher risk of developing its related disorders such as central obesity, dyslipidemia, and hypertension (odds ratio=2.8; 1.8, 1.5, 2.2, and 2.7 for BMI, waist–hip ratio, triglycerides, high-density lipoprotein, and hypertension, respectively). Conclusion The prevalence of Arg64 allele of the Trp64Arg polymorphism in the β3-AR gene is a risk factor for type 2 DM and its related disorders in the Egyptian population.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded28    
    Comments [Add]    

Recommend this journal