• Users Online: 321
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2016  |  Volume : 2  |  Issue : 3  |  Page : 163-166

Study of the relation between the serum level of male sex hormone and peripheral vascular disease in elderly men


1 Department of Internal Medicine, University of Alexandria, Alexandria, Egypt
2 Department of Clinical and Chemical Pathology, University of Alexandria, Alexandria, Egypt

Correspondence Address:
Doaa M Badreldin
5 Eltofola Elsaeda Street, Floor 15, Sidi Beshr Bahari, Alexandria
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2356-8062.200937

Rights and Permissions

Introduction Testosterone hormone decreases consistently with advancing age. Many studies have shown a possible relationship between decreasing level of testosterone and atherosclerosis. Objective The objective of our study was to demonstrate the relationship between male sex hormone [testosterone and sex hormone-binding globulin (SHBG)] concentration and peripheral vascular disease in elderly men. Background Few studies have explored the relationship between serum sex hormones and lower-extremity peripheral arterial disease (PAD) in men. Patients and methods Our study was conducted on 20 elderly men older than 65 years with peripheral vascular disease and 10 healthy age-matched men as controls. Lower-extremity PAD was defined as ankle brachial index less than 0.90 and diagnosis was confirmed with Doppler ultrasound. Radioimmunoassay measured serum levels of total testosterone and SHBG, and we calculated free androgen index level from the mass action equations. Results The results show that serum level of total testosterone, SHBG, and free androgen index were lower in men with peripheral vascular disease than in those without. There is a positive correlation between total testosterone, SHBG, free androgen index, and ankle brachial index. Conclusion Low serum level of total testosterone, SHBG, and free androgen index are significantly and independently associated with the presence of PAD in elderly men.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1091    
    Printed62    
    Emailed0    
    PDF Downloaded25    
    Comments [Add]    

Recommend this journal