• Users Online: 46
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
Year : 2016  |  Volume : 2  |  Issue : 3  |  Page : 131-138

The potential of serum copeptin as a prognostic marker of mortality in patients with sepsis, severe sepsis, or septic shock

1 Internal Medicine Department, Endocrinology Unit, Alexandria Faculty of Medicine, Alexandria University, Alexandria, Egypt
2 Critical Care Department, Alexandria Faculty of Medicine, Alexandria University, Alexandria, Egypt
3 Department of Clinical Pathology, Alexandria Faculty of Medicine, Alexandria University, Alexandria, Egypt
4 Department of Internal Medicine, Alexandria Fever Hospital, Alexandria, Egypt

Correspondence Address:
Tamer M Elsherbiny
Internal Medicine Department, Endocrinology Unit, Internal Medicine Department, Alexandria Faculty of Medicine, Alexandria University, Alexandria - 21411
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2356-8062.200907

Rights and Permissions

Background The present study sought to investigate the correlation of copeptin with the severity of septic status and to analyze the usefulness of copeptin as a predictor of mortality in patients with sepsis, severe sepsis, and septic shock. Patients and methods This prospective observational study was conducted in Alexandria Main University Hospital. The participants were 60 patients who had sepsis, severe sepsis, and septic shock consecutively admitted to the internal medicine ward and the ICU from October 2014 to August 2015. All patients were subjected to full history taking, clinical examination, as well as routine laboratory workup including serum Na+, serum K+, and serum lactate and imaging parameters. Serum copeptin was measured on the first or second day of admission. APACHE II scores were assigned on the basis of the most pessimistic clinical and laboratory data obtained during the first 24 h following admission. Patients were followed up for 10 days after admission, and the 10-day mortality rate was calculated. In addition, 20 age-matched and sex-matched healthy participants were enrolled as controls. Results Measured serum copeptin was significantly increased in groups I, II, and III in comparison with the control group (P<0.001). The value was increasing from sepsis to severe sepsis to septic shock. When patients were followed up for early mortality within 7–10 days, we found that the measured serum copeptin was higher in nonsurvivors than in survivors but without statistically significant difference. It was concluded according to the study of receiver operating characteristic curves that APACHE II score is more sensitive and specific than the serum copeptin when used as a prognostic tool to predict mortality in patients with severe sepsis and septic shock. Conclusion Our data demonstrate that serum copeptin levels increase progressively with the severity of sepsis and may be considered an independent predictor of mortality in severe sepsis and septic shock with superiority of APACHE II scoring.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded34    
    Comments [Add]    
    Cited by others 1    

Recommend this journal