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ORIGINAL ARTICLE
Year : 2016  |  Volume : 2  |  Issue : 1  |  Page : 18-22

Serum chemerin levels and chemerin rs17173608 genotypes in the susceptibility of diabetic nephropathy in Egyptian diabetic patients


1 Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt
2 Department of Biochemistry, Faculty of Medicine, Cairo University, Cairo, Egypt

Correspondence Address:
Yomna Khaled
Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2356-8062.184395

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Background Chemerin, a newly discovered adipokine, highly expressed in obese and insulin resistant patients may provide a link between chronic inflammation and metabolic syndrome. Aim Was to evaluate serum chemerin levels in diabetic nephropathy patients and to evaluate the susceptibility between rs17173608 chemerin gene polymorphism and diabetic nephropathy risk in Egyptian patients. Materials and methods Study was conducted on 105 patients having type 2 diabetes and twenty adult healthy matched controls. Patients were divided into three groups according to urinary albumin excretion (UAE), macroalbuminuric (UAE<300mg/24h), microalbuminurua (30<UAE< 300mg/24h) and normoalbuminuric (UAE<30mg/24h).Serum chemerin levels were measured to all patients and controls by enzyme linked immunosorbent assay.Tetra-amplification refractory mutation system-PCR was performed to detect gene polymorphism. Results Serum chemerin level was significantly elevated in diabetic patients compared to controls. There is significant increase in serum chemerin levels among diabetic subgroups, significantly higher in diabetic patients with macroalbuminuria than in patients with microalbuminuria (P < 0.001) and normoalbuminuria (P = 0.0001). Also it shows highly significant elevation in diabetics with microalbuminuria than in normoalbuminuria (P = 0.0001).Our findings showed a significant association between GT genotypes (OR: 2.95,95% CI = 1.06 to 8.1; P = 0.03 and diabetic patients with macroalbuminuria. In the dominant effect of the G allele (comparison between TG+GG and TT), TG+ GG genotypes were associated with the risk of diabetic macroalbuminuria (OR: 2.8, 95%CI = 1.08to 7.5; P = 0.03). The G allele is dominant and increased the risk of diabetic macroalbuminuria as compared to the T allele (OR = 2.8, 95% CI = 1.01to7.1, P = 0.03). Conclusion Elevated serum chemerin could be marker of diabetic nephropathy and chemerin gene rs17173608 polymorphism is associated with susceptibility of diabetic nephropathy.


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